Volume: 43 Issue: 1
Synthesis of novel anticancer derivatives of a rare phytocompound scillascillin from a new species Ledebouria hyderabadensis
Year: 2021, Page: 9-14, Doi: https://doi.org/10.62029/jmaps.v43i1.Chinthala
Received: May 21, 2021 Accepted: June 15, 2021 Published: July 1, 2021
Ledebouria is a genus of deciduous or weakly evergreen bulbs in the Hyacinthaceae family. This is recognized as the first collection made of the new taxon Ledebouria hyderabadensis. The compound Scillascillin 1 is a rare and novel benzocyclobutene ring containing homoisoflavanone, isolated for the first time from L. hyderabadensis. In vitro anticancer activity performed using MTT assay, on compound 1 and its semi synthetic derivatives showed significant inhibitory activity against human cancer cell lines A549 (Adenocarcinoma), HepG2 (Hepatocellular carcinoma), MCF-7 (breast cancer),SKOV3 (Ovarian Adenocarcinoma)and HeLa(Immortalised). Amongst the derivatives, compound 4 showed better anti-cancer activity against HepG2 (IC50: 61.34 ± 0.31 µM) when compare with parent Scillascillin 1(IC50: 244.69 ± 0.01 µM).
Keywords: Anti-cancer activity, Isolation, Ledebouria hyderabadensis, Scillascillin, Semi-synthesis
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© CSIR-Central Institute of Medicinal and Aromatic Plants, Lucknow-226015
Yakaiah Chinthala, Niranjana Kumar A, Srinivas KVNS, J Kotesh Kumar, Srinivas Chinde, Paramjit Grover. 2021. Synthesis of novel anticancer derivatives of a rare phytocompound scillascillin from a new species Ledebouria hyderabadensis. J Med Aromat Plant Sci 43: 9-14.
