Volume: 43 Issue: 4
Potential Indian medicinal plants during COVID-19 pandemic
Year: 2021, Page: 154-166, Doi: https://doi.org/10.62029/jmaps.v43i4.Verma
Received: Oct. 5, 2021 Accepted: Nov. 25, 2021 Published: Dec. 31, 2021
Severe Acute Respiratory Syndrome (SARS) triggered by the novel coronavirus- SARS-CoV-2 has infected millions of the world population. India is among those countries severely affected due to SARS-CoV-2 with more than 4,20,000 deaths registered and approximately 31.5 million confirmed cases as of 30th July 2021. The 2nd infection wave, caused by the Delta variant of coronavirus was 4-times more transmissible than the original strain. Traditional plant materials are used globally and throughout India as complementary and alternative therapeutics for the control, prevention, and treatment of COVID-19, while no systematic review of studies specifically focussing on studies on Indian traditional medicinal plants against SARSCoV-2 infection during COVID-19 outbreak has been conducted. Aim of the study: This review aims to estimate the comprehensive evaluation of Indian medicinal plants with anti-SARS-CoV-2 activities during the COVID-19 outbreak and to compile the crucial information required for further investigation of their potential role in the management of COVID-19. In vitro, in-silico (computational docking), and in-vivo studies conducted on either crude extracts, phytochemical formulations, or isolated compounds with SARS-CoV-2 potential drug targets viz. Angiotensin-converting enzyme-2 receptors (ACE-2 receptors), SARS-CoV-2 Main Protease (Mpro), viral Spike protein (S Protein), and other humanized models for In-vitro studies have been reported. Hot water and hydroalcoholic extract of medicinal plants like Cissampelos pareira L, and Artemisia annua, have shown the In-vitro inhibition potential against SARS-CoV-2. Formulations based on Withania somnifera, Tinospora cordifolia, and Ocimum sanctum, Carica papaya are found to be potential viral inhibitors.
Keywords: COVID-19, Indian Medicinal plants, In-silico and in-vivo studies, In-vitro, SARS CoV-2
Abdullahi, A. M. (2020). Virology and epidemiology of the 2019 coronavirus disease (COVID-19). Journal of Community Medicine and Public Health Reports, 1(1), 1–8. https://doi.org/10.38207/jcmphr20213
Adegbola, P. I., Semire, B., Fadahunsi, O. S., & Adegoke, A. E. (2021). Molecular docking and ADMET studies of Allium cepa, Azadirachta indica, and Xylopia aethiopica isolates as potential antiviral drugs for COVID-19. VirusDisease, 32, 85–97.
Albohy, A., Zahran, E. M., Abdelmohsen, U. R., Salem, M. A., Al-Warhi, T., Al-Sanea, M. M., Abelyan, N., Khalil, H. E., Desoukey, S. Y., Fouad, M. A., & Kamel, M. S. (2020). Multitarget in-silico studies of Ocimum menthiifolium, family Lamiaceae against SARS-CoV-2 supported by molecular dynamics simulation. Journal of Biomolecular Structure and Dynamics. https://doi.org/10.1080/07391102.2020.1852964
Ammerman, N. C., Beier-Sexton, M., & Azad, A. F. (2008). Growth and maintenance of Vero cell lines. Current Protocols in Microbiology, Appendix(Suppl. 11), Appendix.
Andersen, K. G., Rambaut, A., Lipkin, W. I., Holmes, E. C., & Garry, R. F. (2020). The proximal origin of SARS-CoV-2. Nature Medicine, 26, 450–452.
Artemisia annua. (2021). In Wikipedia. https://en.wikipedia.org/wiki/Artemisia_annua
Balkrishna, A., Pokhrel, S., Singh, H., Joshi, M., Mulay, V. P., Haldar, S., & Varshney, A. (2021). Withanone from Withania somnifera attenuates SARS-CoV-2 RBD and host ACE2 interactions to rescue spike protein-induced pathologies in humanized zebrafish model. Drug Design, Development and Therapy, 15, 1111–1133.
Can Caripill tablets really cure Dengue? (2018, October 25). Catch News. http://www.catchnews.com/health-news/can-caripill-tablets-really-cure-dengue-138340.html
Cascella, M., Rajnik, M., Aleem, A., Dulebohn, S. C., & Di Napoli, R. (2021). Features, evaluation, and treatment of coronavirus (COVID-19). In StatPearls. StatPearls Publishing.
Devpura, G., Tomar, B. S., Nathiya, D., Sharma, A., Bhandari, D., Haldar, S., Balkrishna, A., & Varshney, A. (2021). Randomized placebo-controlled pilot clinical trial on the efficacy of Ayurvedic treatment regime on COVID-19 positive patients. Phytomedicine, 84, 153494.
Gil, C., Ginex, T., Nozal, V., Barrado-Gil, L., Cuesta-Geijo, M. Á., Urquiza, J. J., Ramírez, D., Alonso, C., Campillo, N. E., & Martínez, A. (2020). COVID-19: Drug targets and potential treatments. Journal of Medicinal Chemistry, 63(21), 12359–12386.
RECOVERY Collaborative Group. (2021). Dexamethasone in hospitalized patients with COVID-19. New England Journal of Medicine, 384(8), 693–704.
Haider, M., Anand, V., Dholakia, D., Enayathullah, M. G., Parekh, Y., Ram, S., Kumari, S., Anmol, Bokara, K. K., Sharma, U., Prasher, B., & Mukerji, M. (2021). Anti-SARS-CoV-2 potential of Cissampelos pareira L. identified by connectivity map-based analysis and in vitro studies. bioRxiv. https://doi.org/10.1101/2021.06.11.448155
Haq, F. U., Roman, M., Ahmad, K., Rahman, S. U., Shah, S. M. A., Suleman, N., Ullah, S., Ahmad, I., & Ullah, W. (2020). Artemisia annua: Trials are needed for COVID-19. Phytotherapy Research, 34(10), 2423–2424.
Hariyono, P., Patramurti, C., Candrasari, D. S., & Hariono, M. (2021). An integrated virtual screening of compounds from Carica papaya leaves against multiple protein targets of SARS-CoV-2. Research in Chemistry, 3, 100113.
Islas, J. F., Acosta, E., G-Buentello, Z., Delgado-Gallegos, J. L., Moreno-Treviño, M. G., Escalante, B., & Moreno-Cuevas, J. E. (2020). An overview of Neem (Azadirachta indica) and its potential impact on health. Journal of Functional Foods, 74, 104171.
Kumar, B., Zaidi, S., Haque, S., Dasgupta, N., Hussain, A., Unni, S., Singh, V., & Mishra, B. N. (2020). In-silico studies reveal antiviral effects of traditional Indian spices on COVID-19. Current Pharmaceutical Design, 26.
Li, Y.-D., Chi, W.-Y., Su, J.-H., Ferrall, L., Hung, C.-F., & Wu, T.-C. (2020). Coronavirus vaccine development: From SARS and MERS to COVID-19. Journal of Biomedical Science, 27, 104.
Long, J. Y., Yang, W., Zhen, Q., Hao, M., Yi, Z., Ning, Z. A., Yan, L., & Yuan, X. Z. (2021). The pathogenesis and treatment of COVID-19: A systematic review. Biomedical and Environmental Sciences, 34(1), 50–60.
Mehmood, A., Khan, S., Khan, S., Ahmed, S., Ali, A., Xue, M., Ali, L., Hamza, M., Munir, A., Ur Rehman, S., Mehmood Khan, A., Hussain Shah, A., & Bai, Q. (2021). In-silico analysis of Quranic and prophetic medicinal plants for the treatment of infectious viral diseases including coronavirus. Saudi Journal of Biological Sciences, 28(5), 3137–3151.
Merarchi, M., Dudha, N., Das, B. C., & Garg, M. (2021). Natural products and phytochemicals as potential anti-SARS-CoV-2 drugs. Phytotherapy Research.
Nair, M. S., Huang, Y., Fidock, D. A., Polyak, S. J., Wagoner, J., Towler, M. J., & Weathers, P. J. (2021). Artemisia annua L. extracts inhibit the in vitro replication of SARS-CoV-2 and two of its variants. Journal of Ethnopharmacology, 274, 114016.
Nguyen, T. T. T., Shaw, P. N., Parat, M.-O., & Hewavitharana, A. K. (2013). Anticancer activity of Carica papaya: A review. Molecular Nutrition & Food Research, 57(1), 153–164.
Patel, A., Rajendran, M., Shah, A., Patel, H., Pakala, S. B., & Karyala, P. (2021). Virtual screening of curcumin and its analogs against the spike surface glycoprotein of SARS-CoV-2 and SARS-CoV. Journal of Biomolecular Structure and Dynamics, 1–9.
Pattanayak, P., Behera, P., Das, D., & Panda, S. K. (2010). Ocimum sanctum Linn. A reservoir plant for therapeutic applications: An overview. Pharmacognosy Reviews, 4(7), 95–105.
Prasad, S., & Aggarwal, B. B. (2011). Turmeric, the golden spice: From traditional medicine to modern medicine. In I. F. F. Benzie & S. Wachtel-Galor (Eds.), Herbal medicine: Biomolecular and clinical aspects (2nd ed.). CRC Press/Taylor & Francis.
Rajagopal, K., Varakumar, P., Baliwada, A., & Byran, G. (2020). Activity of phytochemical constituents of Curcuma longa (turmeric) and Andrographis paniculata against coronavirus (COVID-19): An in silico approach. Future Journal of Pharmaceutical Sciences, 6, 104.
Rathi, V., Dhingra, A. K., & Chopra, B. (2021). Withania somnifera. In Naturally occurring chemicals against Alzheimer’s disease (pp. 401–407). Elsevier.
Rattis, B. A. C., Ramos, S. G., & Celes, M. R. N. (2021). Curcumin as a potential treatment for COVID-19. Frontiers in Pharmacology, 12, 1068.
Rosas-Lemus, M., Minasov, G., Shuvalova, L., Inniss, N. L., Kiryukhina, O., Wiersum, G., Kim, Y., Jedrzejczak, R., Maltseva, N. I., Endres, M., Jaroszewski, L., Godzik, A., Joachimiak, A., & Satchell, K. J. F. (2020). The crystal structure of nsp10-nsp16 heterodimer from SARS-CoV-2 in complex with S-adenosylmethionine. bioRxiv. https://doi.org/10.1101/2020.04.17.047498
Salgado, B. S., Monteiro, L. N., & Rocha, N. S. (2011). Allium species poisoning in dogs and cats. Journal of Venomous Animals and Toxins Including Tropical Diseases, 17(1), 4–11.
Satarker, S., & Nampoothiri, M. (2020). Structural proteins in severe acute respiratory syndrome coronavirus-2. Archives of Medical Research, 51(6), 482–491.
Sehailia, M., & Chemat, S. (2020). Antimalarial-agent artemisinin and derivatives portray more potent binding to Lys353 and Lys31-binding hotspots of SARS-CoV-2 spike protein than hydroxychloroquine: Potential repurposing of artenimol for COVID-19. Journal of Biomolecular Structure and Dynamics, 1–11.
Sharma, P., Dwivedee, B. P., Bisht, D., Dash, A. K., & Kumar, D. (2019). The chemical constituents and diverse pharmacological importance of Tinospora cordifolia. Heliyon, 5(9), e02437.
Shree, P., Mishra, P., Selvaraj, C., Singh, S. K., Chaube, R., Garg, N., & Tripathi, Y. B. (2020). Targeting COVID-19 (SARS-CoV-2) main protease through active phytochemicals of Ayurvedic medicinal plants—Withania somnifera (Ashwagandha), Tinospora cordifolia (Giloy), and Ocimum sanctum (Tulsi)—A molecular docking study. Journal of Biomolecular Structure and Dynamics, 1–14.
Sudhakaran, M. V. (2012). Histo-morphological, fluorescent and powder microscopic characterization of Cissampelos pareira Linn. Pharmacognosy Journal, 4(29), 57–68.
Thakkar, S. S., Shelat, F., & Thakor, P. (2021). Magical bullets from an indigenous Indian medicinal plant Tinospora cordifolia: An in silico approach for the antidote of SARS-CoV-2. Egyptian Journal of Petroleum, 30(3), 53–66.
Tsao, S.-M., & Yin, M.-C. (2001). In vitro antimicrobial activity of four diallyl sulphides occurring naturally in garlic and Chinese leek oils. Journal of Medical Microbiology, 50(7), 646–649.
Umar, H. I., Josiah, S. S., Saliu, T. P., Jimoh, T. O., Ajayi, A., & Danjuma, J. B. (2021). In silico analysis of the inhibition of the SARS-CoV-2 main protease by some active compounds from selected African plants. Journal of Taibah University Medical Sciences, 16(2), 162–176.
Ghaffarilaleh, V., Fisher, D., & Henkel, R. (2019). Carica papaya seed extract slows human sperm. Journal of Ethnopharmacology, 241, 111848.
Wilken, R., Veena, M. S., Wang, M. B., & Srivatsan, E. S. (2011). Curcumin: A review of anti-cancer properties and therapeutic activity in head and neck squamous cell carcinoma. Molecular Cancer, 10, 12.
World Health Organization. (2020). Vaccines. https://www.who.int/news-room/q-a-detail/coronavirus-disease-(covid-19)-vaccines
Zhu, Z., Lian, X., Su, X., Wu, W., Marraro, G. A., & Zeng, Y. (2020). From SARS and MERS to COVID-19: A brief summary and comparison of severe acute respiratory infections caused by three highly pathogenic human coronaviruses. Respiratory Research, 21, 224.
© CSIR-Central Institute of Medicinal and Aromatic Plants, Lucknow-226015
Verma, A. K., Verma, T., & Ratnasekhar, C. H. (2021). Potential Indian medicinal plants during COVID-19 pandemic. Journal of Medicinal and Aromatic Plant Sciences, 43(4), 154–166.
