Volume: 43 Issue: 4
Potential Indian medicinal plants during COVID-19 pandemic
Year: 2021, Page: 154-166, Doi: https://doi.org/10.62029/jmaps.v43i4.Verma
Received: Oct. 5, 2021 Accepted: Nov. 25, 2021 Published: Dec. 31, 2021
Severe Acute Respiratory Syndrome (SARS) triggered by the novel coronavirus- SARS-CoV-2 has infected millions of the world population. India is among those countries severely affected due to SARS-CoV-2 with more than 4,20,000 deaths registered and approximately 31.5 million confirmed cases as of 30th July 2021. The 2nd infection wave, caused by the Delta variant of coronavirus was 4-times more transmissible than the original strain. Traditional plant materials are used globally and throughout India as complementary and alternative therapeutics for the control, prevention, and treatment of COVID-19, while no systematic review of studies specifically focussing on studies on Indian traditional medicinal plants against SARSCoV-2 infection during COVID-19 outbreak has been conducted. Aim of the study: This review aims to estimate the comprehensive evaluation of Indian medicinal plants with anti-SARS-CoV-2 activities during the COVID-19 outbreak and to compile the crucial information required for further investigation of their potential role in the management of COVID-19. Invitro, in-silico (computational docking), and in-vivo studies conducted on either crude extracts, phytochemical formulations, or isolated compounds with SARS-CoV-2 potential drug targets viz. Angiotensin-converting enzyme-2 receptors (ACE-2 receptors), SARS-CoV-2 Main Protease (Mpro), viral Spike protein (S Protein), and other humanized models for In-vitro studies have been reported. Hot water and hydroalcoholic extract of medicinal plants like Cissampelos pareira L, and Artemisia annua, have shown the In-vitro inhibition potential against SARS-CoV-2. Formulations based on Withania somnifera, Tinospora cordifolia, and Ocimum sanctum, Carica papaya are found to be potential viral inhibitors.
Keywords: COVID-19, Indian Medicinal plants, In-silico and in-vivo studies, In-vitro, SARS CoV-2
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© CSIR-Central Institute of Medicinal and Aromatic Plants, Lucknow-226015
Verma AK, Verma T, Ratnasekhar CH. 2021. Potential Indian medicinal plants during COVID-19 pandemic. J Med Aromat Plant Sci 43: 154-166.
