Volume: 47 Issue: 2
Phytochemical investigation and anticancer potential of Wattakaka volubilis (L. Fil.) Stapf. stem: A natural Ayurvedic alternative to Murva and Jeevanti
Year: 2025, Page: 83-87, Doi: https://doi.org/10.62029/jmaps.v47i2.shivani
Received: March 12, 2025 Accepted: Aug. 1, 2025 Published: Nov. 30, 2025
The Wattakaka volubilis (L. Fil.) Stapf different plant parts have been used traditionally for different diseases like dyspepsia, diuretic, emetic, expectorant, etc. The plant is used as an alternative to the Ayurvedic herbal drugs Murva and Jeevanti. Chemical examination of the stem yielded two flavonoids: kaempferol 1 and its glycoside, kaempferol-3-O-glucoside 2. In-vitro cytotoxic activity of chloroform extract showed significant inhibition towards HeLa (IC50: 3.2 µg) and A549 (IC50: 2.8 µg) cell lines compared to standard doxorubicin (IC50: 3.2 and 0.8 µg, respectively). Compound 2 showed good cytotoxicity against HT1080 (IC50: 3.0µg) and PANC-1 (IC50: 6.0 µg) cell lines compared to standard doxorubicin (IC50: 1.8 and 3.8 µg, respectively). These findings suggest the therapeutic potential of W. volubilis in cancer treatment.
Keywords: Ayurveda, Cytotoxic activity, Flavonoids, Isolation, Kaempferol, Wattakaka volubilis
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© CSIR-Central Institute of Medicinal and Aromatic Plants, (CSIR-CIMAP), Lucknow, India
Shivani, D., Arigari, N. K., Kumar, J. K., Srinivas, K. V. N. S., & Guru, S. K. (2025). Phytochemical investigation and anticancer potential of Wattakaka volubilis (L. Fil.) Stapf. stem: A natural Ayurvedic alternative to Murva and Jeevanti. Journal of Medicinal and Aromatic Plant Sciences, 47(2), 83–87. https://doi.org/10.62029/jmaps.v47i2.shivani
