Volume: 44 Issue: 1
Fabrication and characterization of CNF/PLGA nanocomposite system for encapsulation of bacoside A3
Year: 2022, Page: 27-37, Doi: https://doi.org/10.62029/jmaps.v44i1.Mishra
Received: April 18, 2022 Accepted: May 18, 2022 Published: Oct. 27, 2022
The inception of nanocellulose-based biodegradable polymeric composites has accomplished astounding application in constructing superior biomaterials. The featuring characteristics of nanocellulose like bio-compatibility, lowcost production, abundance, and toxic-free nature, have paved the way for application in drug delivery. The stability and sustainability of medicinally important constituents of the herbs are also a major concern for the phytopharmaceuticals and nutraceutical industries. Hence, the goal of the present study was to fabricate a composite system of cellulose nanofiber/polylactic-co-glycolide (CNF/PLGA) to encapsulate Bacoside A3 (BA3 ) of Bacopa monnieri plant extract. The stability and sustained release of BA3 at three different pH conditions from the fabricated system were evaluated for its application in the nutraceutical industry. The CNF/PLGA composite system had more storage stability (64%) of BA3 than pure Bacopa extract (47%) for 45 days. The fabricated composite system maintained the antioxidant properties of Bacopa extract. The release of BA3 was sustained in the CNF/ PLGA matrix for up to 24 hours (pH = 9) compared to the control. The release kinetics implies that the BA3 was effectively restrained in the CNF/ PLGA nanocomposite matrix and follows the Korsmeyer-Peppas model and anomalous diffusion mechanism. The hydrolysis of PLGA and mechanical strength of CNF would be responsible for the sustained release of BA3 from the composite system. In summary, the Bacopa extract CNF/PLGA composite system could be an option for the nutraceutical/pharmaceutical product with improved stability and sustained release of its active constituents.
Keywords: Bacoside A3, Cellulose nanofiber, Korsemeyer-peppas, Poly-lactic-co-glycolide
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Mishra D, Shanker K, Khare P. 2022.Fabrication and characterization of CNF/PLGA nanocomposite system for encapsulation of bacoside A3. J Med Aromat Plant Sci 44: 27-37
