Volume: 40 Issue: 1
An update on plants for hair growth promoting activities
Year: 2018, Page: 13-25, Doi: https://doi.org/10.62029/jmaps.v40i1.Rai
Received: Oct. 9, 2018 Accepted: Oct. 25, 2018 Published: Dec. 31, 2018
Hair loss is a dermatological disorder affecting approximately 2% of the population across the globe. The exploration for the hair treatment resulted in the discovery of minoxidil and finasteride approved by USFDA but have remarkable side effects. Plants have now emerged as an effective alternate to the approved drugs and hundreds of plants are reported to have potential for hair growth promotion. Some of the plants are under investigation for their traditional claim for the hair growth, their efficacy and search for their effective molecule. In this review, we have highlighted the plants that are being extensively investigated and used for their hair growth property.
Keywords: CIM-Sfurti, Mucuna Pruriens, Mutation breeding, Variety development
Ali M, Ansari SH. 1997. Hair care and herbal drugs. Indian J Nat Prod 13: 3-5.
Adhirajan N, Ravi Kumar T, Shanmugasundaram N, Babu M. 2003. In vivo and in vitro evaluation of hair growth potential. J Ethnopharmacol 88: 235-239.
Al Snafi AE.2015.The chemical constituents and pharmacological importance of Carthamus tinctorius-An overview. J Pharma Bio 5: 143-166.
Al-Sereiti MR, Abu-Amer KM, Sen P.1999. Pharmacology of rosemary (Rosmarinus officinalis Linn.) and its therapeutic potentials. Indian J Exp Biol 37: 124-130.
Baishiyou Ri. 1993. Hair tonic. Japanese Patent No. 5201833.
Bakhru HK. 1993. Herbs that heal natural remedies for good health (3rd print ed.). New Delhi, Orient Paperbacks. P 117.
Bazzano AN, Hofer R, Thibeau S, Gillispie V Jacobs M, Theall KP. 2016. A review of herbal and pharmaceutical galactagogues for breast-feeding. Ochsner J 16: 511-524.
Begum A, Sandhya S, Ali SS, Vinod KR, Reddy S, Banji D.2013.An in-depth review on the medicinal flora Rosmarinus officinalis (Lamiaceae). Acta Sci Pol Technol Aliment 12: 61-73.
Begum S, Lee M, Gu LJ, Hossain J, Sung CK. 2015. Exogenous stimulation with Eclipta alba promotes hair matrix keratinocyte proliferation and downregulates TGF-ß1 expression in nude mice Int J Mol Med 35: 496-502.
Capuano T. 2005. Las Huellas De Otro Texto Médico En “Don Quijote: Las Virtudes Del Romero”. Romance Note 45: 303-310.
Cha JD, Moon SE, Kim JY, Jung EK, Lee YS.2009. Antibacterial activity of sophora flavanone G isolated from the roots of Sophora flavescens against methicillin-resistant Staphylococcus aureus. Phytother Res 23: 1326-1331.
Cheol, Ryu G. 2004. Hair restorer and manufacturing process there of. KR20040016331.
Choi BM, Oh GS, Lee JW, Mok JY, Kim DK, Jeong SI, Jang SI. 2010. Prenylated chalcone from Sophora flavescens suppresses Th2 chemokine expression induced by cytokines via heme oxygenase-1 in human keratinocytes. Arch Pharma Res 33: 753- 760.
Chopra RN, Nayar SL, Chopra IC. 1956. Glossary of Indian Medicinal Plants. Publication and Information Directorate, CSIR, New Delhi.
Crabtree JS, Kilbourne EJ, Peano BJ, Chippari S, Kenney T, McNally C, Wang W, Harris HA, W inneker RC, Nagpal S, Thompson CC.2010. A mouse model of androgenetic alopecia. Endocrinol 151: 2373- 2380.
Dalby A. 2000. Dangerous Tastes: the story of spices. London British Museum Press 1st Edition, 83-88.
Datta K, Singh AT, Mukherjee A, Bhat B, Ramesh B, Burman AC. 2009. Eclipta alba extract with potential for hair growth promoting activity. J Ethnopharmacol 124: 450-456.
Dawid C, Henze A, Frank O, Glabasnia A, Rupp M, Büning K, Orlikowski D, Bader M, Hofmann T. 2012. Structural and Sensory Characterization of Key Pungent and Tingling Compounds from Black Pepper (Piper nigrum L.) J Agric Food Chem 60: 2884-2895.
Didarshetaban MB, Saeid Pour HR, Kor NM.2013. Fenugreek (Trigonella foenumgraecum L.) as a valuable medicinal plant. Int J Adv Biol Biomed Res 1: 922-931.
Dong HL, Dong SS, Dai YC, Beom JK, Yun YL, Young HK. 2010. Anti-inflammatory and anti-oxidant effects of Sophora flavescens root extraction in lipopolysaccharide-activated raw 264.7 cells. Korean J Med Mycol 15: 39- 50
Dudhatra GB, Mody SK, Awale MM, Patel HB, Modi CM, Kumar A, Kamani DR, Chauhan BN. 2012. A comprehensive review on pharmacotherapeutics of herbal bioenhancers. Scientific World Journal 2012: 637953.
Elzaawely AA, Xuan TD, Tawata S. 2005. Antioxidant and antibacterial activities of Rumex japonicus Houtt. aerial parts. Biol Phara Bull 28: 2225-2230.
Fan L, Zhao HY, Xu M, Zhou L, Guo H, Han J, Wang BR, Guo DA.2009. Qualitative evaluation and quantitative determination of 10 major active components in Carthamus tinctorius L. by high-performance liquid chromatography coupled with diode array detector. J Chromatogr A 1216: 2063-2070.
Feng DQ, Ke CH, Lu CY, Li SJ.2009. Herbal plants as a promising source of natural antifoulants: Evidence from barnacle settlement inhibition. Biofouling 25: 181-190.
Goluch ZS, Koniuszy. 2016. Nutrition of women with hair loss problem during the period of menopause. Prz Menopauzalny 15: 56-61.
Gong J, Fang K, Dong H, Wang D, Hu M, Lu F. 2016. Effect of Fenugreek on Hyperglycaemia and Hyperlipidemia in Diabetes and Prediabetes: a Meta-analysis. J Ethnopharmacol 194: 260-268.
Gotumukkala VK, Annamalai T, Mukhopadhyay TK. 2011. Phytochemical investigation and hair growth studies on the rhizome of N. jatamansi DC. Pharmacogn Mag 7: 146-150.
Gratani L, Varone L. 2004. Leaf key traits of Erica arborea L., Erica multiflora L. and Rosmarinus officinalis L. co-occurring in the Mediterranean maquis. Flora-Morphology, Distribution, Functional Ecol of Pl 199: 58- 69.
Guo S, Feng B, Zhu R, Ma J, Wang W .2011.Preparative isolation of three anthraquinones from Rumex japonicus by high-speed counter-current chromatography. Molecules 16: 1201-1210.
Gupta A, Malviya R, Singh TP, Sharma PK .2010. Indian Medicinal Plants Used in Hair Care Cosmetics: A Short Review. Phcog Net 2: 361-364.
Han JM, An S, Kim MJ, Jin YY, Baek SW, Park JS, Lee WS, Park KH, Jeong TS. 2008. Sophora flavescens attenuates atherosclerosis and hyperlipidemia in LDL receptor deficient mice. Arterioscler Throb Vasl Bio 28: 6.
Hong M H, Lee JY, Jung H, Jin DH, Go HY, Kim JH, Jang BH, Shin YC, Ko SG. 2009. Sophora flavescens Aiton inhibits the production of pro-inflammatory cytokines through inhibition of the NFêB/IêB signal pathway in human mast cell line (HMC-1). Toxicol In Vitro 23: 251-258.
Hunt N, McHale S. 2005. The psychological impact of alopecia. BJM 331: 951-953.
Hwang JH, Lee BM. 2007. Inhibitory effects of plant extracts on tyrosinase, L-DOPA oxidation, and melanin synthesis. J Toxicol Environ Health A 70: 393-407.
Hyun SK, Lee WH, Jeong DM, Kim Y, Choi JS .2008. Inhibitory effects of kurarinol, kuraridinol, and trifolirhizin from Sophora flavescens on tyrosinase and melanin synthesis. Biol Pharm Bull 31: 154-158.
Itigowa M, Ito C, Tan HT, Okuda M, Tokuda H, Nishino H, Furukawa H. 2001. Cancer chemopreventive activity of naphthoquinones and their analogs from Avicennia plants. Cancer Lett 174: 135-139.
Jagel A, Stützel T. 2001. Studies on the morphology and morphogenesis of the seed cones of Platycladus orientalis (L.) Franco, Thuja orientalis L. and Microbiota decussata Kom. (Cupressaceae). Bot Year Syst Bd 123: 337-404.
Jang DS, Kim JM, Kim JH, Kim JS. 2005. 24- nor-Ursane type triterpenoids from the stems of Rumex japonicas. Chem Pharm Bull 53: 1594-1596.
Jaybhaye D, Varma S, Gagne N, bonde V, Gite A, Bhosle D. 2010. Effect of Tectona grandis Linn. seeds on hair growth activity of albino mice. Int J Ayurveda Res 1: 211-215.
Jin JH, Kim JS, Kang SS, Son KH, Chang HW, Kim HP. 2010. Anti-inflammatory and anti-arthritic activity of total flavonoids of the roots of Sophora flavescens. J Ethnopharmcol 127: 589-595.
Kaufman KD. 2002 .Androgens and alopecia. Mol Cell Endocrinol 198: 89-95.
Kim J H, Ryu YB, Kang NS, Lee B W, Heo JS, Jeong IY, Park KH. 2006. Glycosidase inhibitory flavonoids from Sophora flavescens. Biol Pharm Bull 29: 302-305.
Kim HY, Jeong M, Jung HJ, Jung YJ, Yokozawa T, Choi JS. 2008. Hypolipidemic effects of Sophora flavescens and its constituents in poloxamer 407-induced hyperlipidemic and cholesterol-fed rats. Biol Pharm Bull 31: 73-78.
Kirtikar KR, Basu BD. 1975. Indian Medicinal Plants, Vol. II, Jayyed Press, New Delhi, 2nd Edition
Kobayashi N, Suzuki R, Koide C, Suzuki T, Matsuda H, Kubo M. 1993. Effect of leaves of Ginkgo biloba on hair regrowth in C3H strain mice. Yakugaku Zasshi 113: 718-724.
Kumar S, Ambreen H, Variath MT, Rao AR, Agarwal M, Kumar A, Jagannath A. 2016. Utilization of Molecular, Phenotypic, and Geographical Diversity to Develop Compact Composite Core Collection in the Oilseed Crop, Safflower (Carthamus tinctorius L.) through Maximization Strategy. Front Plat Sci 7: 1-14.
Kurup PNV, Ramdas VNK, Joshi P. 1979. Handbook of Medicinal Plants. New Delhi, P 86.
Lee H, Kim Na-H, Yang H, Bae SK, Heo Y, Choudhary I, Kwon YC, Byun JK, Yim HJ, Noh BS, Heo JD, Kim E, KangC. 2016. The Hair Growth-Promoting Effect of Rumex japonicus Houtt. Evid Based Complement Alternat Med 2016: 1873746.
Lee HS, Kim SK, Han JB, Choi HM, Park JH, Kim EC, Choi MS, An HJ, Um JY, Kim HM, Min BI. 2006. Inhibitory effects of Rumex japonicus Houtt. on the development of atopic dermatitis-like skin lesions in NC/Nga mice. Br J Dermtol 155: 33-38.
Lee SS, Zhang B, He M L, Chang VS, Kung HF. 2007. Screening of active ingredients of herbal medicine for interaction with CYP450 3A4. Phytother Res 21: 1096-1099.
Li YP, Takamiyagi A, Ramzi ST, Nonaka S. 2000. Inhibitory effect of Rumex japonicus Houtt on the porphyrin photooxidative reaction. J Dermatol 27: 761-768.
Liu G, Dong J, Wang H, Hashi Y, Chen S. 2011.Characterization of alkaloids in Sophora flavescens Ait. by high-performance liquid chromatography-electrospray ionization tandem mass spectrometry. J Pharm Biomed Anal 54: 1065-1072.
Liu N, Wang LH, Guo LL, Wang GQ, Zhou XP, Jiang Y, Shang J, Murao K, Chen JW, Fu WQ, Zhang GX. 2013. Chronic restraint stress inhibits hair growth via substance p mediated by reactive oxygen species in mice. PLoS One 8: e61574.
Liu W K, Xu SX, Che CT. 2000. Antiproliferative effect of ginseng saponins on human prostate cancer cell line. Life Sci 67: 1297-1306.
Luqman S, Dwivedi GR, Darokar MP, Kalra A, Khanuja SP. 2007. Potential of rosemary oil to be used in drug-resistant infections. Altern Ther Heath Med 13: 54-59.
Manjula V, Selvin Jebaraj Norman T. 2017. Skin healing activity of Naringi crenulata and Phyllanthus reticulatus. The Pharma Inno J 6: 376-378.
Manjula V, Selvin T, Jebaraj Norman, Senthilnathan S. 2017. Naringi crenulata RoxbA potential drug for the future. The Pharma Innovation 6: 261-263.
Matsuda H, Yamazaki M, Asanuma Y, Kubo M. 2003. Promotion of hair growth by Ginseng radix on cultured mouse vibrissal hair follicles. Phytother Res 17: 797-800.
Matsuda H, Yamazaki M, Naruo S, Asanuma Y, Kubo M. 2002. Antiandrogenic and hair growth promoting activities of Lygodii spora (spore of Lygodium japonicum) I. Active constituents inhibiting testosterone 5α- reductase. Biol Pharm Bull 25: 622-626.
Moreno S, Scheyer T, Romano CS, Vojnov AA. 2006. Antioxidant and antibacterial activities of rosemary extracts linked to their polyphenol composition. Free Radic Res 40: 223-231.
Mortel M, Mehta SD. 2013. Systematic review of the efficacy of herbal galactogogues. J Hum Lact 29: 154-162.
Murata K, Takeshita F, Samukawa K, Tani T, Matsuda H. 2011. Effects of ginseng rhizome and ginsenoside Ro on testosterone 5áreductase and hair re-growth in testosterone treated mice. Phytother Res 26: 48-53.
Nadkarni AK. 1954. The Indian Plants and Drugs. Indian Materia Medica 3rd Revised and Enlarged Edition, Popular Prakashan, Bombay, P 291.
O’Neill AR, Badola HK, Dhyani PP, Ranak SK. 2017. Integrating ethnobiological knowledge into biodiversity conservation in the Eastern Himalayas. J Ethnobiol Ethnomed 13: 21.
Ouzir M, El Bairi K, Amzazi S. 2016. Toxicological properties of fenugreek (Trigonella foenum graecum). Food Chem Toxicol 96: 145-154.
Pandit S, Chauhan NS, Dixit VK. 2008. Effect of Cuscuta reflexa Roxb on androgeninduced alopecia. J Cosmet Dermatol 7: 199- 204.
Pant S. 2011. Buxus wallichiana L., a multipurpose Himalayan tree in peril. Int J Biodiver Conserv 3: 175-177.
Park SJ, Nam KW, Lee HJ, Cho EY, Koo U, Mar W. 2009. Neuroprotective effects of an alkaloid-free ethyl acetate extract from the root of Sophora flavescens Ait. Against focal cerebral ischemia in rats. Phytomedicine 16: 1042-1051.
Park WS, Lee CH, Lee BG, Chang IS.2003.The extract of Thuja occidentalis semen inhibited 5alpha-reductase and androchronogenetic alopecia of B6CBAF1/j hybrid mouse. J Dermatol Sci 31: 91-98.
Park WS, Son ED, Nam GW, Kim SH, Noh MS, Lee BG, Jang IS, Kim SE, Lee JJ, Lee CH. 2003.Torilin from Torillis japonica, as a new inhibitor of testosterone 5 alpha reductase. Planta Med 69: 459-461.
Parthasarathy VA, Kandinnan K, Srinivasan V. 2008. Fenugreek. Organic Spices. New India Publishing Agency. Vol. XVI, P 694.
Patel S, Sharma V, Chauhan SN, Dixit VK. 2014. A study on the extracts of Cuscuta reflexa Roxb. in treatment of cyclophosphamide-induced alopecia. Daru 22: 7.
Patel S, Sharma V, Chauhan NS, Thakur M, Dixit VK. 2015. Hair Growth: Focus on Herbal Therapeutic Agent. Curr Drug Discov Technol 12: 21-42.
Paus R. 1998. Principles of hair cycle control. J Dermatol 25: 793-802.
Perera E, Yip L, Sinclair R. 2015. Alopecia areata. Curr Probl Dermatol 47: 67-75.
Prager N, Bickett K, French N, Marcovici G. 2002. A randomized, double-blind, placebo controlled trial to determine the effectiveness of botanically derived inhibitors of 5-alphareductase in the treatment of androgenetic alopecia. J Altern Complement Med 8: 143- 152.
Punasiya R, Verma R, Pillai S. 2014. In vitro hair growth promoting activity of various leaves extract of Hibiscus syriacus L. on albino rat. Int J Pharma Life Sci 5: 3565-3569.
Queralt AV, Regueiro J, Alvarenga JFR, Huelamo MM,LealLN, Raventos RML. 2014. A comprehensive study on the phenolic profile of widely used culinary herbs and spices: Rosemary, thyme, oregano, cinnamon, cumin and bay. Food Chem 154: 299-307.
Rastogi RP, Mehrotra BN. 1998. Compendium of Indian Medicinal Plants. 2nd Reprint, Central Drug Research Institute, Lucknow and National Institute of Science Communication, Council of Scientific and Industrial Research, New Delhi, P 434-436.
Rho SS, Park SJ, Hwang SL, Lee MH, Kim CD, Lee IH, Chang SY, Rang MJ. 2005. The hair growth promoting effect of Asiasari radix extract and its molecular regulation. J Dermatol Sci 38: 89-97.
Roy RK, Thakur M and Dixit VK. 2008. Hair growth promoting activity of Eclipta alba in male albino rats. Arch Dermatol Res 300: 357-364.
Roy RK, Thakur M, Dixit VK. 2007. Development and evaluation of polyherbal formulation for hair growth promoting activity. J Cosmet Dermatol 6: 108-112.
Roy RM, Thakur M, Dixit VK. 2009. Development and evaluation of polyherbal formulation for hair growth promoting activity. Int J Pharmtech Res 4: 1251-1254.
Sahu R, Dhongade H J, Pandey A, Sahu P, Sahu V, Patel D, Kashyap P. 2016. Medicinal properties of Nardostachys jatamansi. Orient J Chem 32: 859-866.
Shanmugapriya R, RamanathanT, Renugadevi G. 2012. Phytochemical characterization and antimicrobial efficiency of mangrove plants Avicennia marina and Avicennia officinalis. Int J Pharmaceu Biol Arch 3: 348-351.
Sharma PC, Yelne MB, Dennis TJ. 2001. Database on medicinal plants used in Ayurveda, Central Council for Research in Ayurveda and Siddha, New Delhi, P 1-3.
Sinha R, Rauniar GP, Panday DR, Adhikari S. 2016. Fenugreek: Pharmacological Actions. Int J Pharm Pharm Sci 5: 1481- 1489.
Srinivasan K. 2007. Black pepper and its pungent principle-piperine: a review of diverse physiological effects. Crit Rev Food Sci Nutr 47: 735-748.
Szaloki Bakos E, Kristof Szvitil I, Pal P. 1997. Hair preparations containing Ginkgo biloba and Liquiritia officinarum extracts for treatment of hair loss. Patent No. BE 1009298. Chem Abs 127: 39461.
Van Beek TA. 2002. Chemical analysis of Ginkgo biloba leaves and extracts. J Chromatogr A 967: 21-55.
Van Beek TA, Montoro P. 2009. Chemical analysis and quality control of Ginkgo biloba leaves, extracts, and phytopharmaceuticals. J Chromatogr A 1216: 2002–2032.
Wan XY, Luo M, Li XD, He P. 2009. Hepatoprotective and antihepatocarcinogenic effects of glycyrrhizin and matrine. Chem Biol Interact 181: 15-19.
Watanabe C, Naito Y. 1991. Hair tonics containing hormones and Ginkgo extracts. Patent No. JP 03161426 115: 214519.
Wijaya WH, Munim A, Joshita D. 2013. Effectiveness test of fenugreek seed (Trigonella foenum-graecum L.) extract hair tonic in hair growth activity. Int J Curr Res 5: 3453-3460.
Xie QC, Yang YP. 2014. Anti-proliferative of physcion 8-O-ß-glucopyranoside isolated from Rumex japonicus Houtt. on A549 cell lines via inducing apoptosis and cell cycle arrest. BMC Complement Altern Med 6: 377.
Yadav R, Kaushik R. 2011. A study of phytochemical constituent and pharmacological actions of Trigonella foenum-graecum: A review. Int J Pharm Technol 3: 1022-1028.
Yun TK. 2001. Brief introduction of Panax ginseng C.A. Meyer. J Korean Med Sci 16 (Suppl): S3-5.
Zee OP, Kim DK, Kwon HC, Lee KR. 1998. A new epoxynaphthoquinol from Rumex japonicas. Arch Pharm Res 21: 485-486.
Zhang NN, Park DK, Park HJ. 2013. Hair growth-promoting activity of hot water extract of Thuja orientalis. BMC Complement Altern Med 13: 9.
Zhang X, Lan Z, Dong XP, Deng Y, Hu XM, Peng T, Guo P. 2007. Study on the active components of Nardostachys chinensis. Zhong Yao Cai 30: 38-41.
Zhang Y, Zhu H, Ye G, Huang C, Yang Y, Chen R, Yu Y, Cui X. 2006. Antiviral effects of sophoridine against coxsackie virus B3 and its pharmacokinetics in rats. Life Sci 78: 1998- 2005.
Zhou H, Lutterodt H, Cheng Z, Yu L. 2009. Anti-Inflammatory and antiproliferative activities of trifolirhizin, a flavonoid from Sophora flavescens roots. J Agric Food Chem 57: 4580–4585.
Zhou X, Xuan L, Zhang S. 2005. Study on the chemical constituents from Rumex japonicus Houtt. Zhong Yao Cai 28: 104-105.
Zhu ZC, Wang HZ, Yang F. 2009. Composite sophorae injection in prevention of toxicity and adverse effects caused by chemotherapeutic agents. J Pratical Oncol 24: 592-594
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Prashant Rai, Abha Meena, Narayan Prasad Yadav, Suaib Luqman. 2018. An update on plants for hair growth promoting activities. J Med Aromat Plant Sci 40: 13-25.